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Description:Full size table Next, we tried to reveal the reason why the type-3 is the most dominant and why the type-2 is unlikely when there is no spacer. For this purpose, we performed the additional simulations in which one of the Cores is fixed on the RE and interactions between the other Cores and the RE are turned off. From these simulations, we calculated the spatial probability distribution of the core domain that forms dimers with the fixed core domain. From this figure, we can see that the high probability iso-surface is around the binding site next to the fixed Core, indicating that this topological constraint is one of the reasons why the type-3 is the most dominant and why the type-2 is unlikely.

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